This document provides an overview of PFAS, followed by an in depth discussion of PFAS in 10 key issue areas. Each issue paper describes the many PFAS initiatives taken and underway in Minnesota and identifies key areas of opportunity moving forward on managing and addressing PFAS. The papers also highlight the significant interconnections between different areas, illustrating the complexity and difficulty of managing PFAS. The issue papers cover a broad range of topics. Across all those topics, themes emerge among the needed actions.