The Tox21 10K Compound Library

Read the full story from U.S. EPA.

The Tox21 10K Compound Library brings together a wealth of chemical testing methods, samples and data from EPA, partner agencies and other science institutions to help scientists evaluate chemicals for potential health effects. The 10K Compound Library is the largest of its kind, specifically intended to be used in high-throughput in vitro assay screens to advance the understanding of chemical toxicology.

The library is the result of a decade-long effort and acts as the foundation for Toxicology Testing in the 21st Century (Tox21). The Tox21 consortium is a federal collaboration between EPA, the National Toxicology Program (NTP) headquartered at the National Institute of Environmental Health Sciences (NIEHS), the National Center for Advancing Translational Sciences (NCATS) and the Food and Drug Administration (FDA).

A paper written by EPA researcher Dr. Ann Richard and colleagues, The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology, describes how the library has advanced scientific understanding of chemical toxicology. The paper was recognized as an American Chemical Society (ACS) Editor’s Choice in November 2020.

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